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Personalized Precision Medicine

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Coronavirus Spike pdb id: 7df3 Xu C, Wang Y, Liu C, Zhang C, Han W, Hong X, Wang Y, Hong Q, Wang S, Zhao Q, Wang Y, Yang Y, Chen K, Zheng W, Kong L, Wang F, Zuo Q, Huang Z, Cong Y. Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM. Sci Adv. 2021 Jan 1;7(1):eabe5575. doi: 10.1126/sciadv.abe5575. PMID: 33277323; PMCID: PMC7775788.

 Antibody B12 pdb id: 1hzh Saphire EO, Parren PW, Pantophlet R, Zwick MB, Morris GM, Rudd PM, Dwek RA, Stanfield RL, Burton DR, Wilson IA. Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design. Science. 2001 Aug 10;293(5532):1155-9. doi: 10.1126/science.1061692. PMID: 11498595.

 ACE2 pdb id: 6m1d Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science. 2020 Mar 27;367(6485):1444-1448. doi: 10.1126/science.abb2762. Epub 2020 Mar 4. PMID: 32132184; PMCID: PMC7164635.

Coronavirus Polymerase pdb id: 6yyt Hillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P. Structure of replicating SARS-CoV-2 polymerase. Nature. 2020 Aug;584(7819):154-156. doi: 10.1038/s41586-020-2368-8. Epub 2020 May 21. PMID: 32438371.

Taq pdb id: 1taq Kim Y, Eom SH, Wang J, Lee DS, Suh SW, Steitz TA. Crystal structure of Thermus aquaticus DNA polymerase. Nature. 1995 Aug 17;376(6541):612-6. doi: 10.1038/376612a0. PMID: 7637814.

MoMLV RT polymerase pdb id: 5dmq Tang X, Zhu Y, Baker SL, Bowler MW, Chen BJ, Chen C, Hogg JR, Goff SP, Song H. Structural basis of suppression of host translation termination by Moloney Murine Leukemia Virus. Nat Commun. 2016 Jun 22;7:12070. doi: 10.1038/ncomms12070. PMID: 27329342; PMCID: PMC4917968.

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